Gabapentin, marketed under the brand name Neurontin among others, is a medication used to treat epilepsy, neuropathic pain, hot flashes, and restless leg syndrome. In epilepsy it may be used for those with partial seizures. It is recommended as one of a number of first line medications for the treatment of neuropathic pain in diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. For neuropathic pain about 14% of people have a meaningful benefit.
There is weak evidence that gabapentin provides meaningful pain relief for around 14% of people who take it for fibromyalgia and chronic neuropathic pain. Evidence is very little for neuropathic pain from conditions other than postherpetic neuralgia, diabetic neuropathy, and fibromyaligia. It may be helpful in neuropathic pain due tocancer.
It is not effective in HIV-associated sensory neuropathy. When used for neuropathic pain it does not appear superior to carbamazepine. It appears to be as effective as pregabalin and costs less. It does not appear to provide benefit for complex regional pain syndrome
Gabapentin may reduce opioid use following surgery, but does not help with chronic pain after surgery. There is no evidence that it is useful for migraine prevention.
By http://gabapentinneurontin.org/, Gabapentin Can be used for a lot of Nerve Pain related health conditions.including Cough, Hot Flashes, Alcohol Withdrawal, Anxiety 161 reviews, Bipolar Disorder, Trigeminal Neuralgia, Postherpetic Neuralgia, Migraine, Insomnia， Occipital Neuralgia， Peripheral Neuropathy，Vulvodynia, Benign Essential Tremor, Epilepsy, Fibromyalgia, Pain Relief, Diabetic Peripheral Neuropathy , Neuropathic Pain，Reflex Sympathetic Dystrophy Syndrome，Periodic Limb Movement Disorder， Spondylolisthesis， Burning Mouth Syndrome，Pudendal Neuralgia， Small Fiber Neuropathy.
A lot of Patients use Gabapentin (Neurontin) to treat Hot Flashes, Anxiety, Bipolar Disorder, Migraine, Insomnia, Restless Legs Syndrome, Peripheral Neuropathy, Fibromyalgia, Neuropathic Pain. Fe patients use gabapentin to treat Pruritus, Cough, Occipital Neuralgia, Benign Essential Tremor, ement Disorder, Spondylolisthesis, Burning Mouth Syndrome, Pudendal Neuralgia, Small Fiber Neuropathy.
Gabapentin Mechanism Of Action, The mechanism of the anticonvulsant action of gabapentin has not been fully described. Though similar in structure to the endogenous neurotransmitter GABA, gabapentin has not been shown to bind to GABA receptors at concentrations at or below 1 mM. Gabapentin modulates the action of glutamate decarboxylase (GAD) and branched chain aminotransferase (BCAT), two enzymes involved in GABA biosynthesis. In human and rat studies, gabapentin was found to increase GABA biosynthesis, and to increase non-synaptic GABA neurotransmission in vitro.
Gabapentin has been shown to bind to the α2δ-1 subunit of voltage gated calcium ion channels which attributes to its pain attenuation effects in diabetic neuropathy and post-herpetic neuralgia. Other neurophysiological findings indicate that gabapentin also interacts with NMDA receptors, protein kinase C, and inflammatory cytokine
How should I take gabapentin (Neurontin)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
The Horizant brand of gabapentin should not be taken during the day. For best results, take Horizant with food at about 5:00 in the evening.
The Neurontin brand of gabapentin can be taken with or without food.
If you break a tablet and take one half of it, take the other half at your next dose. Any tablet that has been broken should be used as soon as possible or within a few days.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not stop taking gabapentin for seizures without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using gabapentin suddenly. You may need to use less and less before you stop the medication completely.
Contact your doctor if your seizures get worse or you have them more often while taking gabapentin.
Wear a medical alert tag or carry an ID card stating that you take gabapentin. Any doctor, dentist, or emergency medical care provider who treats you should know that you take seizure medication.
Use gabapentin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using gabapentin.
Store gabapentin tablets and capsules at room temperature away from light and moisture.
Store the liquid medicine in the refrigerator. Do not freeze.
What happens if I miss a dose (Neurontin)?
What happens if I overdose (Neurontin)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include blurred vision, drowsiness, weakness, slurred speech, or diarrhea.
What should I avoid while taking gabapentin (Neurontin)?
This medication may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Avoid taking an antacid within 2 hours before or after you take gabapentin. Antacids can make it harder for your body to absorb gabapentin.
What other drugs will affect gabapentin (Neurontin)?
Tell your doctor about all other medicines you use, especially:
- hydrocodone (Lortab, Vicodin, Vicoprofen, and others);
- morphine (Kadian, MS Contin, Oramorph, and others); or
- naproxen (Naprosyn, Aleve, Anaprox, and others).
This list is not complete and other drugs may interact with gabapentin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.