Category: Gabapentin

Gabapentin is the generic name of a prescription drug used to treat epilepsy. Gabapentin works by decreasing abnormal excitement in the brain. It also may change the way the body senses pain. Gabapentin is in a class of medications called anticonvulsants.

The U.S. Food and Drug Administration (FDA) approved gabapentin in 1993 under the brand name Neurontin for the drug manufacturer Pfizer. The medication comes in capsule form, as a regular or extended-release tablet, and as a liquid.

Gabapentin interacts with voltage-sensitive calcium channels in cortical neurons. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters.

One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus.

This is mediated through its binding to presynaptic NMDA receptors.  Other studies have shown that the antihyperalgesic and antiallodynic effects of gabapentin are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha-2 adrenergic receptors.  Gabapentin has also been shown to bind and activate the adenosine A1 receptor.

Gabapentin may help to control your condition but will not cure it. Continue to take gabapentin even if you feel well. Do not stop taking gabapentin without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood.

If you suddenly stop taking gabapentin tablets, capsules, or oral solution, you may experience withdrawal symptoms such as anxiety, difficulty falling asleep or staying asleep, nausea, pain, and sweating. If you are taking gabapentin to treat seizures and you suddenly stop taking the medication, you may experience seizures more often.

Your doctor may decrease your dose gradually over at least a week.